Always consult your physician before taking Duratia. This Sildenafil and Dapoxetine combination should not be taken by men under 18 years of age. Do not drive or perform any activity requiring alertness, while taking these pills. If you are allergic to any of the active constituents, do not consume these pills. Avoid concurrent use of Duratia and nitrates, blood pressure-lowering medicines. Also, avoid drinking alcohol and consuming grapefruit products,and fatty food if you are taking Duratia.